Rat-liver Mitochondria and Microsomes
نویسنده
چکیده
Work by Marinetti, Erbland & Stotz (1958) on pig-heart-cell fractions and by Macfarlane, Gray & Wheeldon (1960) on rat-liver-cell fractions have indicated that the mitochondrial and microsomal phospholipids may differ significantly in composition. In view of the results obtained by Collins (1960) and by Collins & Shotlander (1961), showing the widespread occurrence of complex amino-phospholipids, which have not been detected by other workers, it was important to examine the phospholipids in liver-cell fractions with the procedures described by Collins & Shotlander (1961). Table 1. Phospholipids of rat-liver-cell fractions
منابع مشابه
The lipid composition of rat-liver mitochondria, fluffy layer and microsomes.
The fatty acid compositions of the intracellular organelles of rat liver, separated by differential centrifuging, and the composition of the rat-liver lipids, have been described by Getz & Bartley (1961) and Getz, Bartley, Stirpe, Notton & Renshaw (1961). This paper describes the lipid composition of the mitochondria, fluffy layer and microsomes isolated from rat liver. A similar study has rece...
متن کاملMetabolic activation and DNA adduct formation of Benzo(a) pyrene by adult and newborn rat skin and liver microsomes
Benzo(a) pyrene is a carcinigen polycyclic aromatic hydrocarbon which diffuses into the environment from combustion of organic meterials.based on various epidemiological evidences it is related to lung,skin and liver cancer.mutagenicity,and immunosuppressivety are among important biological effects of Benzo(a) pyrene.after absorbtion and distribution in the body,it undergoes epoxidation by cyto...
متن کاملPhospholipid synthesis and exchange between rat liver microsomes and mitochondria in the presence of benzo(a)pyrene.
Benzo(a)pyrene injection increased the phospholipid content in membranes of rat liver mitochondria and microsomes. There was a large relative increase of phosphatidylcholine, especially in microsomes, as compared with normal liver. The quantity of phosphatidylethanolamine seemed not be affected and the other phospholipid classes decreased. In vivo [U-14C]glycerol incorporation into phospholipid...
متن کاملInitial stages in the incorporation of amino acids into protein in rat-liver mitochondria.
The addition of cell sap is required for the incorporation of amino acids into rat-liver microsomes and ribosomes (Hoagland, Keller & Zamecnik, 1956; Komer, 1961). The function of the sap involves activation of the amino acids to form amino acyl adenylates (Hoagland et al. 1956) and the subsequent transfer of the activated amino acids to a soluble RNA (Hoagland, Stephenson, Scott, Hecht & Zamec...
متن کاملA Comparison of Toxicity Mechanisms of Cigarette Smoke on Isolated Mitochondria Obtained from Rat Liver and Skin
Previous studies demonstrated that CSE induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of CSE in human health and disease. The present study was carried out to further characterize and compare toxic effect of CSE extract on isolated mitochondria obtained from either a directly contacting tissue (i...
متن کاملPropofol Attenuates Toxic Oxidative Stress by CCl4 in Liver Mitochondria and Blood in Rat
Anti-oxidant effects of propofol (2, 6-diisopropylphenol) were evaluated agains carbon tetrachloridet CCl4 -induced oxidative stress in rat liver. 30 male rats were equally divided in to 6 groups (5 rats each). Group I (control), while Group II was given CCl4 (3 mL /Kg/day, IP). Animals of Groups III received only propofol (10 mg/Kg/day, IP). Group IV was given propofol+ CCl4. Group V was admin...
متن کامل